2017-Sustainable Industrial Processing Summit
SIPS 2017 Volume 5. Marquis Intl. Symp. / New and Advanced Materials and Technologies

Editors:Kongoli F, Marquis F, Chikhradze N
Publisher:Flogen Star OUTREACH
Publication Year:2017
Pages:590 pages
ISSN:2291-1227 (Metals and Materials Processing in a Clean Environment Series)
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    Synthetic Bone Biomaterial: Physicochemical and Biological Investigations

    Hassane Oudadesse1; S MOSBAHI1; S JEBAHI2; A. Lucas-Girot1; H. Elfeki2; A. Elfeki2; G. Cathelineau1;
    1UNIVERSITY OF RENNES 1, Rennes, France; 2UNIVERSITY OF SFAX, Sfax, Tunisia;
    Type of Paper: Regular
    Id Paper: 190
    Topic: 43


    Synthetic biomaterials such as calcium phosphate, calcium carbonate, geopolymers and bioactive glasses offer several opportunities for applications in orthopedic or jawbone surgery. Physicochemical and biological properties such as crystalline structure, mechanical properties, biocompatibility and kinetic of ossification are necessary for the success of biomaterials. In this work calcium carbonate in the aragonite form and bioactive glasses have been studied. Their association with antibiotic, biopolymers or bisphosphonate for the treatment of bone pathologies were performed.
    Calcium carbonate was synthesized at low temperatures. Obtained powder was compacted, mixed with porogens to create porosity (44% in this study) and implanted in the femoral site of ovine. A bioactive glass was elaborated by melting process and implanted in the tibia plates of rabbits. Several physicochemical techniques X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Neutron Activation Analysis (NAA) and Protons Induced X-rays Emission (PIXE) were employed to evaluate the in vitro and the in vivo behavior of these biomaterials. Histological studies were performed to analyze the eventual inflammations in the implanted area and to highlight the effects of introduced organic molecules in the matrix of biomaterials on the osteoporosis phenomenon.
    Obtained results show that mineral composition of these two biomaterials undergoes some transformations versus time of implantation in the femoral site. Concentrations of atomic elements such as Ca, P, Sr and Zn present spectacular variations versus time. Few weeks for bioactive glass and few months of CaCO3 after implantation, mineral composition of the initial implants is close to the mineral composition of the mature bone.
    Cartographies were performed on the surfaces of the biomaterials, on the interface bonebiomaterial and on the bone. Obtained results show a good bioconsolidation of these two biomaterials.
    Treatment of osteoporosis was observed when a specific bisphosphonate is present in the biomaterial matrix.



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    Oudadesse H, MOSBAHI S, JEBAHI S, Lucas-Girot A, Elfeki H, Elfeki A, Cathelineau G. (2017). Synthetic Bone Biomaterial: Physicochemical and Biological Investigations. In Kongoli F, Marquis F, Chikhradze N (Eds.), Sustainable Industrial Processing Summit SIPS 2017 Volume 5. Marquis Intl. Symp. / New and Advanced Materials and Technologies (pp. 187-188). Montreal, Canada: FLOGEN Star Outreach