2017-Sustainable Industrial Processing Summit
SIPS 2017 Volume 5. Marquis Intl. Symp. / New and Advanced Materials and Technologies
| Editors: | Kongoli F, Marquis F, Chikhradze N |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2017 |
| Pages: | 590 pages |
| ISBN: | 978-1-987820-69-0 |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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Hybrid Bio-Composite Glass-Chitosan Used for Applications in Biomedical Field
Hassane Oudadesse1; S MOSBAHI1; S JEBAHI2; H. Elfeki2; A. Elfeki2; H. Keskes2;1UNIVERSITY OF RENNES 1, Rennes, France; 2UNIVERSITY OF SFAX, Sfax, Tunisia;
Type of Paper: Regular
Id Paper: 191
Topic: 43
Abstract:
The hybrid composite consisting on the association of bioactive glass and chitosan biopolymer was elaborated by using an original process based on freeze-dried process and lyophilisation principle.
This hybrid biocomposite offers several applications and advantages in dental,maxilo-facial and orthopedic surgery. Using this kind of biomaterial could enhance a direct bond to the living bone through the development of the surface layer of carbonated apatite and serves for therapeutic treatment such as osteoporosis phenomenon.
The bioactive glass was synthesized in the SiO2 (46% wt.) - CaO (24% wt.) - Na2O (24% wt.) and P2O5 (6%wt.) system. The amount of introduced chitosan was of 17% wt. Chitosan was mixed with glass powder following several steps. Hybrid bio-composite was then implanted in the femoral site of ovarioctomized rates. Sampling has been carried out after a different period.
Biological and physicochemical characterizations such as XRD, SEM, FTIR, MAS-NMR,
mechanical characteristics and other techniques have employed to highlight this bio-
composite behavior after in vivo assays. Effects of chitosan on the osteoporosis created following the ovarioctomization have been studied.
Obtained results show good biocompatibility of bio-composite. The biological apatite is deposed since the first month after implanted as showed by SEM. It crystallizes in hexagonal system, which corresponds to the crystallographic structure of mature bone. 13C solid-state MAS NMR investigated the organic moiety of the bone Extra Cellular Matrix (ECM).
Obtained spectra of native femoral condyle bone, show the typical spectral signature of collagen. 29Si and 31P were also investigated. The kinetic of ossification revealed that at 3 months of implantation, the hybrid bio-composite was completely transformed into bone.
Osteoinduction phenomenon and antiosteoporotic effects of chitosan were highlighted in the ovariectomised rates by using histological investigations.