2018-Sustainable Industrial Processing Summit
SIPS2018 Volume 4. Mamalis Intl. Symp. / Advanced Manufacturing

Editors:F. Kongoli, A. G. Mamalis, K. Hokamoto
Publisher:Flogen Star OUTREACH
Publication Year:2018
Pages:352 pages
ISBN:978-1-987820-88-1
ISSN:2291-1227 (Metals and Materials Processing in a Clean Environment Series)
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    Nanotechnology Enables Hot Gold Nanorods to Kill Cancer Cells and to Stop Live Cells from Migrating

    Mostafa A. El-Sayed1;
    1GEORGIA INSTITUTE OF TECHNOLOGY, Atlanta, United States;
    Type of Paper: Keynote
    Id Paper: 12
    Topic: 48

    Abstract:

    Cancer claims the lives many people after several years of suffering and after unsuccessfully using a great deal of different treatments, like surgery, chemical and/or radiation treatments. The field of nanotechnology showed us how different materials acquire so many different properties when their size is reduced to the nanometer scale. Gold nanoparticles having rod shape of nanometer size and a length/width ratio of 3:1 can absorb near infrared light (to which our body is transparent) and convert it into heat. If solution containing gold nanorods is injected into a cancer lump and exposed to near infrared light the hot solution (resulting from the gold nanorods upon absorbing the near infra-red light) melts the cancer cells leading to their death. This was demonstrated by our group in the photo-thermal destruction and destroying cancer cells in solution, in cancer lumps in small and in large animals. [1-4]
    Normally, some of the cancer cells that do not die are able to migrate to other parts of the body, away from the location of their initial formation spot, until they are located in a sensitive part of the body that leads to cancer patient death. This process in which cancer cells migrate is called metastasis.
    Very recently, however, we discovered [5] that in our photo-thermal treatment, while treating cancer cells in the first cancer location with hot gold nano-rods, the cancer cell's legs and arms and the motion proteins are photo-thermally destroyed. This makes it difficult for the cancer cells to migrate to new and more important functional locations in the body. This treatment is thus effective in stopping cancer cell migration through the patient body and increases the success rate of the patient recovery.

    Keywords:

    Biomedical engineering; Nanotechnology/Nanomaterials manufacturing; Cancer treatment; Photothermal;

    References:

    [1] El-Sayed, I. H.; Huang, X.; El-Sayed, M. A. Cancer Lett. 2006, 239, (1), 129-135.
    [2] Dickerson, E. B.; Dreaden, E. C.; Huang, X.; El-Sayed, I. H.; Chu, H.; Pushpanketh, S.;
    McDonald, J. F.; El-Sayed, M. A. Cancer Lett. 2008, 269, (1), 57-66.
    [3] Rahman MR, Ali MRK, Zhao Z, Chen GZ, El-Sayed MA and Shin DM. CancerResearch 2016, 76, (14).
    [4] Ali MRK, Ibrahim IM, Ali HR, Selim SA, El-Sayed MA. International Journal of Nanomedicine 2016:11 1-15
    [5] Moustafa RK Ali, Yue Wu, Deepraj Ghosh, Brian H Do, Kuangcai Chen, Michelle R Dawson, Ning Fang, Todd A Sulchek, Mostafa A El-Sayed, Proc. National Academy of Science, 2017.,114 (28): E5655-E5663.

    Cite this article as:

    El-Sayed M. (2018). Nanotechnology Enables Hot Gold Nanorods to Kill Cancer Cells and to Stop Live Cells from Migrating. In F. Kongoli, A. G. Mamalis, K. Hokamoto (Eds.), Sustainable Industrial Processing Summit SIPS2018 Volume 4. Mamalis Intl. Symp. / Advanced Manufacturing (pp. 315-316). Montreal, Canada: FLOGEN Star Outreach