2019-Sustainable Industrial Processing Summit
SIPS2019 Volume 13: Composite, Ceramic, Nanomaterials, Polymers, and Mathematics
| Editors: | F. Kongoli, M. de Campos, S. Lewis, S. Miller, S. Thomas |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2019 |
| Pages: | 171 pages |
| ISBN: | 978-1-989820-12-4 |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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Fabrication of Multi-Layered Gold-Silica-Gadolinium Compound Core-Shell Particles and their Applications to X-ray Imaging and Magnetic Resonance Imaging
Yuta Shindo1; Tomoya Inose2; Noriko Yamauchi1; Kouichi Nakashima1; Masayuki Tokunaga2; Chihiro Kato2; Kohsuke Gonda2; Yoshio Kobayashi1;1IBARAKI UNIVERSITY, Hitachi, Japan; 2TOHOKU UNIVERSITY, Sendai, Japan;
Type of Paper: Regular
Id Paper: 6
Topic: 16
Abstract:
Materials composed of components that have different properties should have multiple functions. Various composite particles with magnetism and X-ray absorption abilities have been developed. Based on the viewpoint for multi-functionalization of materials, particles containing gold (Au) and gadolinium compounds (GdC) will act as both the X-ray contrast agent and the MRI contrast agent. In our previous work [1], the silica (SiO2)-coating of metallic Au nanoparticles has been performed by using a modified Stober method. Our other previous works have proposed methods for GdC-coating particles such as the SiO2 [2] and SiO2-coated quantum dot [3,4]. The present work proposes a method for preparing multi-layered core-shell particles composed of the core of Au, the first shell of SiO2, and the second shell of GdC (Au/SiO2/GdC), which is a combination of the various coating techniques developed in our previous works [1-4]. Imaging abilities based on both X-ray absorption and magnetic resonances of the multi-layered core-shell particle colloid solution were also studied in the present work.
The Au nanoparticles were produced by reducing hydrogen tetrachloroaurate (III) trihydrate with trisodium citrate dihydrate. SiO2-coated Au (Au/SiO2) nanoparticles were fabricated by a sol-gel reaction in the presence of the Au nanoparticles. Multi-layered Au/SiO2/GdC nanoparticles were fabricated by a homogeneous precipitation reaction in the presence of Au/SiO2 nanoparticles.
The Au nanoparticles, the Au/SiO2 nanoparticles, and the multilayered Au/SiO2/GdC nanoparticles had average sizes of 15.5, 38.0, and 43.8 nm, respectively. The computed tomography (CT) value of the Au/SiO2/GdC colloid solution containing 4.3x10-2 M Au was 606 HU: Its converted CT value (CT value divided by Au concentration) was 1.4x104 HU M-1. The longitudinal relaxation rate (r1) of the Au/SiO2/GdC colloid solution was 2.3 mM-1 s-1.
In conclusion, the Au/SiO2/GdC colloid solution was found to function as the X-ray contrast agent and the MRI contrast agent.
Keywords:
Core-Shell; Nanoparticles; Sol-Gel;References:
[1] Y. Kobayashi, H. Inose, T. Nakagawa, K. Gonda, M. Takeda, N. Ohuchi, A. Kasuya, J. Colloid Interface Sci. 358 (2011) 329-333.[2] Y. Kobayashi, J. Imai, D. Nagao, M. Takeda, N. Ohuchi, A. Kasuya, M. Konno, Colloids Surf. A 308 (2007) 14-19.
[3] Y. Kobayashi, T. Nozawa, T. Nakagawa, K. Gonda, M. Takeda, N. Ohuchi, A. Kasuya, J. Sol-Gel Sci. Technol. 55 (2010) 79-85.
[4] Y. Kobayashi, T. Nozawa, M. Takeda, N. Ohuchi, A. Kasuya, J. Chem. Eng. Jpn. 43 (2010) 490-493.