| Involvement of anti-oxidant Twendee X in immunity. Fuhua Yang1; Naomi Okada2; Haruhiko Inufusa3; Toshikazu Yoshikawa4; 1DIVISION OF ANTI-OXIDANT RESEARCH, GIFU UNIVERSITY, Gifu, Japan; 2GIFU UNIVERSITY, Gifu, Japan; 3TIMA, Gifu, Japan; 4LOUIS PASTEUR CENTER, Kyoto, Japan; PAPER: 103/Oxidative/Regular (Oral) SCHEDULED: 15:15/Wed. 30 Nov. 2022/Ballroom B ABSTRACT: Many diseases and physical disorders are caused by both external and internal factors, but the common denominator is inflammation and oxidative stress. Suppressing oxidative stress on a daily basis and maintaining a high level of self-immunity can help prevent and treat disease and maintain good health. Intestines are involved in about 60% of our immune system. There are over 100 species of, or 100 trillions of bacteria in our intestines, and their ideal balance is 20% of good, 10% of bad, and 70% of opportunistic bacteria. This balance is lost by disturbed life rhythm and various diseases, in other words “oxidative stress”, being said to decrease bacterial diversity. Reducing oxidative stress and increasing diversity of intestinal bacteria is important for maintaining healthy life. Composed of vitamins, CoQ10, and amino acids, Twendee X (TwX) is an antioxidant which is confirmed to have a dementia-prevention effect. Effects of oxidative stress reduction by taking antioxidants on the bacterial diversity of the intestinal microflora and the balance of the intestinal microflora are examined. Rats were given an antifungal agent OPP for 2 weeks, then blood and feces samples were collected to analyze blood oxidative stress and intestinal bacterial diversity. TwX was administrated from 1 week before OPP initiation. Although OPP rat group increased blood oxidative stress by 5%, no significant change was observed in microbial flora diversity. A rat group given TwX since 1 week before decreased oxidative stress by 13.3% and increased bacterial diversity 1.5 times higher, compared to rats which wasn’t given, and the number of Akkermansia, anti-inflammatory bacteria, was increased 3.5 times more. In the questionnaire survey for healthy participants who were given TwX for 1 month, the number of good bacteria and intestinal bacterial diversity were increased. Their defecation status and QOL were improved with that. TwX tends to reduce oxidative stress, to increase the number of bacteria and diversity in intestinal microflora. It was suggested that this enables to protect human body from harmful substances invaded inside, improve immune system, and improve daily defecation status and QOL. References: 1. Novel compositions and uses thereof WO 2008071790 A3 2. Antioxidant composition and its use in diabetes EP 1932542 A1 3. Composition for accelerating alcohol metabolism and for reducing the risk of alcohol induced diseases WO 2012095509 A8 4. Composition for moderating triglyceride and cholesterol levels WO 2009062910 A1 |
