| The antioxidant Twendee X and cancer treatment Naomi Okada1; Fuhua Yang2; Taku Nakashima3; Haruhiko Inufusa4; Toshikazu Yoshikawa5; 1GIFU UNIVERSITY, Gifu, Japan; 2DIVISION OF ANTI-OXIDANT RESEARCH, GIFU UNIVERSITY, Gifu, Japan; 3DEPARTMENT OF MOLECULAR AND INTERNAL MEDICINE, GRADUATE SCHOOL OF BIOMEDICAL & HEALTH SCIENCES, HIROSHIMA UNIVERSITY, Hiroshima, Japan; 4TIMA, Gifu, Japan; 5LOUIS PASTEUR CENTER, Kyoto, Japan; PAPER: 124/Oxidative/Regular (Oral) SCHEDULED: 12:20/Mon. 28 Nov. 2022/Ballroom B ABSTRACT: As examples of cancer treatment, immunotherapy is now widely recognized as a powerful cancer therapy in addition to conventional therapies such as operation, chemotherapy and radiotherapy. Although they are all effective treatments, chemotherapy and radiotherapy, which take advantage of small differences between cancer cell (tumor cell) and normal cell, damage normal cells as well as cancer cells. As a result, adverse events are almost inevitable and are often difficult to continue treatment depending on the degree. As these treatments are administered over months or years, physical and mental damage accumulate, leading to a decline in physical strength and immunity. These adverse events are largely due to oxidative stress. That is, the tumor itself, and reactive oxygen species (ROS) generated by treatment for it, can cause damage to various cells due to oxidative stress. And oxidative stress can cause a decline in physical strength and immunity, which leads to tumor growth and a negative spiral. Thus, suppression of oxidative stress in tumor and cancer treatment may be very effective in not only alleviating symptoms but also prolonging prognosis. Since oxidative stress-mediated mechanisms of carcinogenesis also exist, suppression of oxidative stress may help to prevent cancer. An antioxidant compound Twendee X (TWX) which composed of vitamins, amino acids, and CoQ 10 is rated as the strongest and safe antioxidant in the world by ICDD (France). Cytoprotective effects of TWX against radiation exposure were examined using murine alveolar epithelial cells (LA-4). After allowing LA-4 cells to adhere, 25ug/ml of TWX was added in the medium. The cells were irradiated with 30Gy of radiation 2 hours after the addition, and after 72 hours, the effect on cell proliferative capacity was examined. The result showed that TWX significantly inhibited the radiation-induced decrease in cell proliferative capacity. In addition, TWX can be used in single and continuous doses in both healthy and pregnant mice and also increased NK activity, which is tumor immunity. In summary, TWX not only reduced adverse events during cancer treatment but also increased tumor immunity. We believe TWX can be an aid in the treatment and prevention of cancer. References: 1. Novel compositions and uses thereof WO 2008071790 A3 2. Antioxidant composition and its use in diabetes EP 1932542 A1 3. Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress. Yusuke Izumi, Taku Nakashima, Noboru Hattori, Free Radic Biol Med.2019;136:52-59 4. Balancing efficacy of and host immune responses to cancer therapy:the yin and yang effects. Shbaked Y, Nat Rev Clin Oncol.2016 Oct;13(10):611-26. 5. Systematic Review: Generating Evidence-Based Guidelines on the Concurrent Use of Dietary Antioxidants and Chemotherapy or Radiotherapy. Akiko Nakayama, Karen P, Obianuju Lgbokwe, and Leffrey D. white. Cancer Invest. 2011 Dec:29(10): 655-667. |
