2023-Sustainable Industrial Processing Summit
Ozawa Intl. Symp. / Oxidative Stress of Human Beings

Editors:	F. Kongoli, T. Yoshikawa, H. Inufusa, C. A. Amatore, H-Y. Chen, W-H. Huang, H. Van Goor
Publisher:	Flogen Star OUTREACH
Publication Year:	2023
Pages:	96 pages
ISBN:	978-1-989820-84-1 (CD)
ISSN:	2291-1227 (Metals and Materials Processing in a Clean Environment Series)

CD shopping page

EFFECTS OF ANTI-OXIDANT, TWENDEE X, FOR REGENERATION OF THE VOCAL FOLD AFTER SURGERY

Shigeru Hirano¹; Mami Kaneko²; Yoichiro Sugiyama³; HARUHIKO INUFUSA⁴;
¹KYOTO PREFECTURAL U. OF MEDICINE, Kyoto, Japan; ²KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, Kyoto, Japan; ³DEPARTMENT OF OTOLARYNOGOLGY-HEAD AND NECK SURGERY, KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, Kyoto, Japan; ⁴GIFU UNIVERSITY, Gifu, Japan;
Type of Paper: Plenary
Id Paper: 121
Topic: 54

Abstract:

The vocal fold is a vibratory mucosa essential for creating voice, but it is fragile after injury, and once it is scarred, voice becomes hoarse and harsh, which is difficult to recover. Regeneration of the mucosa after injury is important to avoid such dysphonia. Our previous research indicated that oxidative stress is one of the leading issues that causes scarring of the vocal fold, and anti-oxidant can preserve the tissue. The current clinical trial examined the effects of the strong anti-oxidant, Twendee X (TWX), on regeneration of the vocal fold after surgery.
Materials and Methods: Ten patients received surgery for vocal fold pathologies including polyp, leukoplakia, CIS, etc. They were randomly assigned to TWX group which were treated with TWX perioperatively and control group without TWX treatment. The vocal fold function after the surgery was assessed at 1 to 3 months using stroboscopy and acoustic parameters.
TWX group indicated significantly better vibratory parameters on stroboscopy at 1 month through 3 months as compared to the control group. TWX group also showed better GRBAS scale and loudness of the voice.
TWX was shown to be effective for better recovery of the vocal fold after surgery with less scarring.

Keywords:

Anti-Oxidants; Oxidative Stress; Free Radicals; Reactive Oxygen Species (ROS);


Cite this article as:

Hirano S, Kaneko M, Sugiyama Y, INUFUSA H. (2023). EFFECTS OF ANTI-OXIDANT, TWENDEE X, FOR REGENERATION OF THE VOCAL FOLD AFTER SURGERY. In F. Kongoli, T. Yoshikawa, H. Inufusa, C. A. Amatore, H-Y. Chen, W-H. Huang, H. Van Goor (Eds.), Sustainable Industrial Processing Summit Ozawa Intl. Symp. / Oxidative Stress of Human Beings (pp. 67-68). Montreal, Canada: FLOGEN Star Outreach