2023-Sustainable Industrial Processing Summit
Ozawa Intl. Symp. / Oxidative Stress of Human Beings
| Editors: | F. Kongoli, T. Yoshikawa, H. Inufusa, C. A. Amatore, H-Y. Chen, W-H. Huang, H. Van Goor |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2023 |
| Pages: | 96 pages |
| ISBN: | 978-1-989820-84-1 (CD) |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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WHY TWENDEE X SUCCESSFULLY PREVENTED DEMENTIA?
HARUHIKO INUFUSA1; Fuhua YANG1; Yoshiaki Harakawa1; Toshikazu Yoshikawa2;1GIFU UNIVERSITY, Gifu, Japan; 2LOUIS PASTEUR MEDICAL RESEARCH CENTER, Kyoto, Japan;
Type of Paper: Plenary
Id Paper: 152
Topic: 54
Abstract:
Many different types of dementia exist, with Alzheimer's disease (AD) accounting for the majority of cases.
The greatest risk factor for AD is aging, which is the result of oxidative stress that has accumulated over the years. In addition, amyloid-β accumulated in the AD brain generates free radicals that cause inflammation in the surrounding neurons, leading to mitochondrial dysfunction and eventual neurodegeneration. In other words, the development of AD is the result of a vicious cycle of oxidative stress, inflammation, and mitochondrial dysfunction established over a long period of time, and the progression of AD is no exception.
The pathogenesis of AD is said to occur 20 years before clinical symptoms appear. Therefore, starting treatment after the onset of symptoms could be too late to be effective.
Twendee X (TwX, Oxicut®︎) is an antioxidant formula shown to have a preventive effect for human mild cognitive impairment (MCI) in a multicenter, randomized, double-blind, placebo-controlled, prospective intervention trial. Previous studies have shown that in diabetes, which hastens cognitive decline, TwX intake not only lowers blood glucose levels but also suppresses autophagy dysfunction. TwX has also been shown to positively affect neurogenesis in the hippocampal dentate gyrus, telomere elongation, and mitochondrial function. This suggests that TwX may prevent or halt the progression of dementia from all angles.
This study suggests that TwX may not only prevent dementia, but may also aid in its treatment.
Keywords:
Anti-Oxidants; Mitochondria; Alzheimer Disease; Autophagy; Oxidative Stress; Reactive Oxygen Species (ROS); Twendee XReferences:
1. Tadokoro K, Morihara R, Abe K, et al. Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study. J Alzheimers Dis. 2019; 71(3): 1063-1069.2. Inufusa H. Characterization of cell protection effects of Twendee X by oxidative stress. J World Mitochondria Soc. 2016; 2: 42.
3. Haruhiko I. Composition for protection against cytotoxic effects. Tima Foundation. Patent No. 5777821. 2015-9-9.
4. Feng T, Yamashita T, Abe K, et al. In Vitro Free Radical Scavenging Activities of Dietary Supplements by Electron Spin Resonance. Brain Supplements. 2020; 2: 1-12.