2023-Sustainable Industrial Processing Summit
Ozawa Intl. Symp. / Oxidative Stress of Human Beings
| Editors: | F. Kongoli, T. Yoshikawa, H. Inufusa, C. A. Amatore, H-Y. Chen, W-H. Huang, H. Van Goor |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2023 |
| Pages: | 96 pages |
| ISBN: | 978-1-989820-84-1 (CD) |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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OXIDATIVE CONTRIBUTION TO CELLULAR SENESCENCE IN THE BRAIN
Julie Andersen1;1BUCK INSTITUTE FOR RESEARCH IN AGING, Novato, United States;
Type of Paper: Regular
Id Paper: 218
Topic: 54
Abstract:
Oxidative stress has long been considered to contribute to brain aging and age-related neurodegenerative disorders including Parkinson’s and Alzheimer’s disease1. Data over the last few years suggests that one important mechanism driving neuropathology associated with these disorders is a process known as cellular senescence. In response to stressors including agents which elicit oxidative or proteotoxic stress, cells may undergo conversion to a resting state where they are not capable of replicating and forming tumors. However, maintenance of these cells over long periods of time in the aging organism can result in increased inflammatory events known as the senescent associated secretory phenotype or SASP which is damaging to neighboring tissues, including within the brain. Here, I will present data suggesting that not only does cellular senescence occur in conjunction with age-related neurodegenerative diseases, but that elimination of senescent cells may constitute a therapeutic avenue for these disorders2-4. This is dependent however on selectivity of senescent cell removal which avoids off-target effects on other cell types.
Keywords:
Ageing; Alzheimer Disease; Cellular Oxidative Damage; Neurodegenerative Diseases; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species (ROS)References:
[1] Walton and Andersen (2019). Unknown fates of (brain) oxidation: close encounter with neuronal senescence. FRBM 134: 695-701.[2] Chinta, Woods, et al. (2018). Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson’s disease. Cell Rep. 22:930-940.