2025 - Sustainable Industrial Processing Summit
SIPS2025 Volume 2. Inufusa Intl. Symp. / Oxidative Stress and Technological Innovations in Medicine
| Editors: | F. Kongoli, K. Abe, W. Cho, K. Fukui, S. Hirano, D. Joseph, T. Yoshikawa, J.R. Ribas, N. Tran |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2025 |
| Pages: | 282 pages |
| ISBN: | 978-1-998384-40-2 (CD) |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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COMBINATION ANTIOXIDANT SUPPLEMENT, TWENDEE X IMPROVES COGNITIVE AND MOTOR FUNCTION IN MIDDLE-AGED MICE
Koji Fukui1; Yoshiaki Harakawa2; Fuhua Yang2; Haruhiko Inufusa2;1SHIBAURA INSTITUTE OF TECHNOLOGY, Saitama, Japan; 2GIFU UNIVERSITY, Gifu, Japan;
Type of Paper: Invited
Id Paper: 150
Topic: 54
Abstract:
Reactive oxygen species (ROS) are closely associated with brain dysfunction, particularly cognitive decline, which often accompanies aging. Antioxidant supplementation is a promising strategy to mitigate these effects [1,2]. In this study, we investigated the effects of Twendee X, a combination antioxidant supplement containing eight active ingredients, on cognitive and motor functions in middle-aged mice. Male C57BL/6 mice (49 weeks old) were administered Twendee X orally for one month. Behavioral assessments using the Morris water maze test revealed significant improvements in spatial memory, while the Rota-rod test indicated enhanced motor coordination. To explore the potential mechanisms underlying these effects, we performed western blot analyses of neurotrophic factors in the brain; however, no significant changes were detected among the experimental groups. These results suggest that combination antioxidant supplementation may enhance brain function in aging individuals, although the precise molecular mechanisms remain to be elucidated. Regular antioxidant intake may contribute to the prevention of age-related cognitive and motor decline.