| Brain Disease and Oxidative Stress: Ischemia and Dementia Haruhiko Inufusa1; Koji Abe2; Isao Tadokoro2; Fuhua (fukka) Yang (you)3; Toshikazu Yoshikawa4; 1TIMA JAPAN CORPORATION, Gifu, Japan; 2DEPARTMENT OF NEUROLOGY, GRADUATE SCHOOL OF MEDICINE, DENTISTRY AND PHARMACEUTICAL SCIENCES, OKAYAMA UNIVERSITY, Okayama, Japan; 3GIFU UNIVERSITY DIVISION OF ANAEROBE RESEARCH, Gifu, Japan; 4LOUIS PASTEUR CENTER FOR MED. RES., Tohoku, Japan; PAPER: 229/Oxidative/Regular (Oral) SCHEDULED: 15:15/Thu. 24 Oct. 2019/Zeus (55/Mezz. F) ABSTRACT: Reactive Oxygen Species (ROS) are closely related to various diseases of the brain. Twendee X (TWX) is an antioxidant composition consisting of Vitamin C, L-Glutamine, L-Cystine or L-Cysteine, Riboflavin, Succinic acid, Fumaric acid, Coenzyme Q10, and Niacin. TWX was invented from the basic experiments of alcohol, glucose, and fat metabolisms (1-4). TWX strongly reduces ROS (Patent: WIPO WO2013/072441 A1, COMPOSITION FOR PROTECTION AGAINST CELL-DAMAGING EFFECTS). Lysozyme radiation experiments showed that the antioxidant effects of TWX are 6-7 times higher than Vitamin C (Data from Dr. Helmut Durschschlarg, Regensburg Univ. Germany). Oxidative stress and mitochondrial expert ICDD (France) experiments using hepatic cancer cell line HepG2 showed TWX decrease of 63% of mitochondrial ROS and an increase of 147% mitochondrial SOD. ICDD confirmed that TWX is safe and has most strong anti-ROS and protection effects from ROS. TWX increase Neogenesis nerves cell numbers of the hippocampal dentate gyrus of the 56 weeks mouse. The same occurs within 6 weeks by TWX administration. The mitochondrial metabolism of the mouse’s hippocampal dentate gyrus was activated by TWX administration by the metabolome analysis. The model of the brain of the mouse for ischemia and Alzheimer's disease were used to evaluate the effects of TWX. The double blind clinical trial of the Japanese Association for Prevention of Dementia from autumn 2017 to March 2019 for mild cognitive impairment was performed to analyze TWX prevention effects on Alzheimer's disease. TWX decreased volume of brain ischemia to 2/3, and inflammation and oxidative stress in the brain was also reduced in the mouse ischemia model. TWX inhibited deposition of amyloid beta. Inflammation and oxidative stress in the brain was also reduced in the mouse model of Alzheimer. Double blind clinical research resulted in the TWX group significantly increasing the score of the Mini Mental State Examination compared to the placebo group at 6 months after the start of TWX administration. Thus, TWX is effective to prevent Alzheimer's disease and vascular dementia. References: 1. Novel compositions and uses thereof WO 2008071790 A3<br />2. Antioxidant composition and its use in diabetes EP 1932542 A1<br />3. Pretreatment Twendee X reduced acute ischemic brain damage. Kusaki M, Inufusa H, Abe K, JSCVD 2017; 26: 1191-1196<br />4. Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion. XiaLiu, Abe K https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.029 |
