| Oxidative Stress Disease (Free Radical Disease) and its Prevention - Appearance of the Effective Antioxidant Material Toshikazu Yoshikawa1; 1LOUIS PASTEUR CENTER FOR MED. RES., Tohoku, Japan; PAPER: 478/Oxidative/Regular (Oral) SCHEDULED: 14:00/Thu. 24 Oct. 2019/Zeus (55/Mezz. F) ABSTRACT: It is widely known that oxidative stress causes many diseases. Free radical species triggering these results from transition metals, ischemia/reperfusion, drugs, inflammation, and environmental factors such as iron, and it causes the pathologies. Materials and mechanisms that are essential to the survival of many organisms including cells, protein and DNA is ruined by a free radical, causing many diseases, and these diseases were proposed that we called these oxidation stress diseases (free radical diseases) as a general term. A lot of specialized international journals about these are proud of the impact factor which is high in each. Although the disorder developmental mechanics and protective efficacy are studied in vitro and in animal experiments in detail, there is yet few antioxidative prevention or drugs to treat for those diseases in clinical studies using human. Drug RADICUT (cut a free radical according to the name. Generic name “Edaravone”) used for brain stroke treatment widely or vitamin E effective in non-alcoholic lipid hepatitis (NASH) are the representative examples. These and other antioxidants cannot be an effective means for treatment and prevention of many other oxidative stress diseases probably because of the characteristics of the drugs. Appearance of a versatile antioxidant material which expresses an effect of prevention and treatment for many oxidation stress diseases without showing any side effects has been waited for. A supplement named Twendee X which was the vitamins and amino acids complex showing strong antioxidant effect finally came up recently. Ingredients and composition ratio of Twendee X was developed to maximize its antioxidant effects. The randomized, double-blind placebo control study of dementia prevention using Twendee X for human with mild cognitive impairment (MCI) was conducted by Professor Koji Abe of the Okayama University, Department of Neurology. Surprisingly, the result showed its preventive effect of MCI progression with a significant difference [1], and, as for this antioxidant material, it has been suggested to be effective in the prevention and treatment of many oxidative stress diseases, and more results are expected in the future. Here, based on these results, I will discuss about possibility of prevention and treatment by antioxidant materials. References: [1] J Alzheimers Dis. 2019 Aug 24. doi: 10.3233/JAD-190644 |
