The following are the subjects to be treated at this international symposium:
The human immune system uses the final products of oxidative stress to protect the human body from bacterial or virus infections. However, an excess of oxidative stress is closely related to almost all diseases as well as aging. In this symposium presentations will be widely accepted related but not limited to basic research as well as practical applications on these diseases and their symptoms
COVID-19, virus infection, allergy
Oxidative stress and immune activity are closely related with disease or symptoms. Allergic reaction depending on imbalance of immune system which is easy to damage by oxidative stress. AIDS infection to white blood cell resulted huge dose secretion of oxidative stress, induces immunosuppression and various diseased including malignancy. Pneumonia of COVID-19 corona virus infection is totally different from ordinary pneumonia by bacteria infection. COVID-19 pneumonia starts lower and back side of lung and CT scan shows typical interstitial pneumonia. Interstitial pneumonia is kind of allergic reaction, thus pneumonia start high blood flow area of lung and very rapidly spread to the whole lung. It is well known that interstitial pneumonia shows very high oxidative stress, damages lung tissue, and some patients shows irreversible damage on lung. Once immune systems over run, it causes fatal cytokine storm. Fatal risks of COVID-19 virus infection are high age with underline disease. Especially diabetes mellitus, obesity, heart disease, hypertension, after stroke, cancer, neurogenic disorder, dementia and so on. All these risk factors show very high oxidative stress. In other word, Risk factor of COVID-19 virus infection is oxidative stress. In human life, oxidative stress is most low at newborn, increase slowly till age 30, increase to high level at age over 70. Low oxidative stress will be one of reason why child infected COVID-19 virus usually no symptoms or no severe condition. Kawasaki disease like vasculitis in young child and cerebral infraction in mid age are reported at New York or Spain by COVID-19 infection. Oxidative stress damages vascular endothelium and inflammation of vascular wall produces thrombosis. Oxidative stress is major role in these symptoms.
The level of oxidative stress in the human body is the lowest at birth and stay low up to the age of 30. This level increases after the age of 30. Very high levels of oxidative stress in the human body have been found in children that suffer from progeria, a well-known genetic disease that makes the body to age very fast and causes premature death before age of 20. As a consequence, reducing oxidative stress may prevent various disease and prolong human life as well. Mitochondria, an organelle or a specialized cell subunit that is found in every cell of the human body except red blood cells is a resource of oxidative stress that produces energy and detox of human body. As such, controlling mitochondrial functions related to aging is subject of numerous scientific researches worldwide. Aging and the quality of life are important factors for sustainable development.
Sleep Apnea, a potentially serious sleep disorder in which breathing repeatedly stops and starts, has been shown to be directly related to tragedies such as Exxon Valdez oil spill, Space Shuttle Challenger disaster or many traffic accidents. In USA, over 40 million patients suffering from Sleep Apnea are cause of direct economic losses of 15,900 million USD per year and indirect losses of 100 billion USD per year, making it a serious social risk that negatively affects sustainable development. It has been shown that humans that suffer from Sleep Apnea have high oxidative stress levels that have been positively correlated with its symptoms. As such, reducing oxidative stress is very important factor in treating Sleep Apnea patients.
Recent research published in the international academic specialized magazine "Human Reproduction Update" gives shocking information that sperms counts in males has decreased by 52% during the last 40 years.
It is known that sperm can be damaged by smoke, alcohol abuse, electromagnetic waves (cell phone), radiation, microwave, UV and diseases (diabetes, cancer). All latter factors increase oxidative stress in the human body. People are not aware that Bisphenol A used in plastics and aspartame used as a sweetener in coffees are very strong chemicals that increase oxidative stress and reduce sperm count in males. As such an effective strategy is required related to human reproduction in the view of sustainable development.
Ovum is also damaged by oxidative stress. After the age 36, ovum membrane hardens and this is one of reasons of having difficult fertilization after that age. Oxidative stress also damages ovum DNA and causes an increase potential for genetic abnormalities.
Recently, research on bacterial flora is an important topic in scientific research because of the facts that 60% of human immune systems depends on intestinal bacterial flora. Oxidative stress levels in humans are also effected by intestinal bacterial flora. Scientist believes that a proper control of intestinal bacterial flora may reduce oxidative stress and prevent various disease. This is because human lives coexist with a huge number of bacteria in it.
Cancer cells produce oxidative stress in the human body. Oxidative stress damages the human immune system similar to a natural killer and decreases its ability to fight cancer. An increased level of oxidative stress induces also inflammation which causes additional problems in the human body. Clinical "activities of daily living" correlate well with the amount of oxidative stress in cancer patients. As a result, targeting oxidative stress in the cancer patients is very important in the fight against cancer.
Presentations are welcomed on various topics that include but will not be limited to:
Measuring of the oxidative stress in persons suffering from the above conditions and specifically in patients fighting cancer
Practical treatment with anti-oxidative stress agents of persons suffering from the above conditions and specifically in patients fighting cancer.
Any research or conclusion related to the above issues or alternative treatments.
Role of reactive species (ROS, RNS, RSS) in evolution, healthy and pathological conditions, and contemporary medicine.
- Oxidative Stress
- Reactive Oxygen Species (ROS)
- Reactive Nitrogen Species (RNS)
- Reactive Sulfur Species (RSS)
- Free Radicals
- Hydrogen peroxide
- Nitric Oxide
Dr. Haruhiko Inufusa was born Okayama Japan at 1957. After finished Medical School Kindai University at 1982, he starts work at Surgery department of Kindai University Hospital. At the period of post graduate school of Kindai University, he started research of cancer especially on metastasis phenomenon. He established various cancer cell lines, and one cell line had potential of metastasis in nude mouse. He achieved principal graduation by this research result at 1988. Cancer and glycolipid was his main research target during his post doctor fellowship position 1988-1990 at University Washington Seattle, Professor Sen-itchiro Hakomori laboratory,. Later, he found that Lewis Y glycolipid of cancer controls blood coagulation and metastasis as well. In 2001, he was promoted professor at Kindai University School of Medicine (Department of Surgery) and Faculty of Agriculture (Department of Clinical Nutrition). Acting as a surgeon, he was one of first 15 doctors in Japan who started laparoscopic surgery for colorectal cancer, and his surgical video was widely used to educate young doctors. In 2006 he resigned from his position of Director of Advanced Medical Technology and Medical Economics, at Kindai University School of Medicine. He starts research on alcohol, sugar, and fat metabolism at TIMA Japan Inc. which supported by TIMA foundation. After invention of anti-alcohol supplement SUPLAIV, he invented Twendee X that activate sugar and fat metabolisms. Strong anti-oxidant effects of Twendee X were found at 2011, he starts producing and marketing SUPAILV and Twendee X by the request of TIMA foundation. At 2013, Gifu university started his laboratory Division of Antioxidant Research. His present main invention is the successful treatment of various patients with Twendee X.
Christian Amatore, 65, was educated at Ecole Normale Superieure (ENS), the leading French center for higher education and research. He held the former position of Louis Pasteur at ENS. He is now Emeritus Director of Research in CNRS, Full Member of the French Academie des Sciences where he served as a vice-President in charge of Education, Foreign Member of the Chinese Academy of Sciences, Member of the Academia Europae, Member of The Third World Academy of Sciences, Honorary Fellow of the Royal Society of Chemistry and of the Chinese Chemical Society, Honorary Member of the Israeli Chemical Society, Distinguished Scientist of the French Chemical Society, President and now Past President of the International Society of Electrochemistry. Over the past years he acted as one of the twenty members of the High Council of Science and Technology which advised the French Governments on scientific matters. He has been thrice knighted by the French Republic in the Order of National Merits, the Order of Legion d'Honneur for his scientific achievements, as well in the Order of Academic Palms for his deep involvement for scientific education in universities but also in elementary, middle and high schools. His researches involve the development of advanced electrochemical concepts, methodologies and instrumentation for investigating extremely complex mechanisms of organic and organometallic chemistry under the very conditions used by synthetic chemists. Amatore's activity in molecular kinetics is best illustrated by the rationalization of electron transfer catalysis, electron transfer activation of molecules and more recently by a thorough series of works relative to the elucidation of the most important mechanistic aspects of catalysis by homogeneous palladium complexes, an extremely active area in today's catalysis for carbon-carbon bond making in fine chemical industry. The well recognized contributions of Amatore's group in this area have opened new views for rationalizing these important processes which have already led to the development of new synthetic strategies. Amatore's contributions gave electrochemistry new concepts and new tools that are essential in offering electrochemistry new entries in several mechanistic problems in organic, inorganic, and organometallic chemistries and more recently into the biology of living cells. His researches were published in 485 primary research publications cumulating above 21 100 citations and corresponding to a "h-index" of 73 (ISI Web of Science, May 2017) with an average citations rate above 1 200 per year over the past 5 years. Amatore received many important French and international awards and distinctions among which the Silver Medal (CNRS), the Reilley Award (SEAC), the de Broglie Medal (Academia dei Lincei), the Bourke Medal (RSC), the Galvani Medal (SCI), the Breyer Medal (RACI), the Heyrovsky award (Charles University, Prague), the Faraday Medal (RSC), and the Volta Medal (ECS). He has been distinguished lecturer in many outstanding universities (Royal Society (London), Oxford, Durham, Cornell, Pittsburgh, Prague, Caltech, Padova, Modena, Roma La Sapienza, Japan JSPS, Bologna, etc.) and is Honorary Professor or Doctor Honoris Causa of several universities in Europe and Asia.
Professor Hong-Yuan Chen, academician of the Chinese Academy of Sciences and ACS Fellow, has started his research career in Analytical Chemistry at Nanjing University (China) since the early 1960s. He was as a Visiting Scholar at the Mainz University in West Germany in period of 1981~84 supported by Adenaur Stiftung. He acted as the National Representative of China in IUPAC during 1991-94. He is the founder and director of the State Key Laboratory of Analytical Chemistry for Life Science, a world-renowned research base in the field of analytical chemistry. His research focuses on bioanalytical chemistry, electrochemistry, microfluidic Lab-on-a-Chip, nanoscience, nanotechnology and biomedical engineering, especially for the analysis of single cells. He has co-authored over 900 papers with citation over 32,600 times, H-index 91, 8 books, and over 400 oral lectures. He also served as the advisory board member for Analytical Chemistry (ACS) and ACS Sensors. In 2015, Professor Chen was recognized as Nature Lifetime Award for Outstanding Scientific Mentoring by the Nature Publishing Group.
Dr. Wei-Hua Huang is currently a Professor in the College of Chemistry and Molecular Sciences at Wuhan University. He got his Bachelor Degree and Doctoral Degree from Wuhan University in 1996 and 2002, respectively, and then stayed therein as a faculty. After spending one year at Ecole Normale Superieure as a Postdoctor, he has been a full professor at Wuhan University from 2007. His primary research interests focus on development of micro or nanoscale analytical techniques and explore their use in the monitoring of single cells. He has expertise in biosensors, electroanalytical chemistry, and microfluidics. He has published more than 90 publications in the peer-reviewed journal including such as Angew. Chem. Int. Ed., JACS, ACS Nano, Chem. Sci., Anal. Chem. and Lab Chip. His research has been supported by a number of grants from Natural Science Foundation of China (NSFC), Ministry of Science and Technology of China (MOST) and other funding agencies. He has won several awards including the first prize of Natural Science in Hubei Province, the Program for New Century Excellent Talents in University of Ministry of Education (MOE), and the National Science Foundation for Distinguished Young Scholars.
Professor Harry van Goor his main research line concerns the role of oxidative stress in various healthy and disease conditions. He studies ROS as a biomarker of disease severity and as a marker of anti-oxidant and anti-inflammatory therapy response. He is author on 300 papers and has a Hirsch factor of 67. Currently he is the President of yearly Redox meetings in Paris and the Middle East.
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