In Honor of Nobel Laureate Prof. M Stanley Whittingham
| PROTECTION OF VOCAL FOLD BY BASIC FIBROBLAST GROWTH FACTOR Shigeru Hirano1; 1KYOTO PREFECTURAL U. OF MEDICINE, Kyoto, Japan; PAPER: 129/Oxidative/Regular (Oral) OL SCHEDULED: 17:10/Tue. 28 Nov. 2023/Dreams 1 ABSTRACT: Background: The vocal fold is a vibratory mucosa essential for creating voice, but it is fragile after injury, and once it is scarred, voice becomes hoarse and harsh, which is difficult to recover. Our previous research indicated that oxidative stress can cause scarring of injured vocal folds, and anti-oxidant can avoid the scarring. Basic fibroblast growth factor (FGF) has been proved to have anti-oxidant effects in vascular sclerosis. The current study examined the effects of FGF for preservation of the vocal fold after injury. Materials and Methods: Sprague Dawley rats were used as the model of vocal fold injury. Unilateral vocal fold was resected and immediately treated with FGF or saline injection (sham control). Scarring of the vocal folds were assessed at 2 months after the injury. Results: FGF group showed better wound healing with less scarring as compared to the sham. Hyaluronic acid was significantly better preserved. Gene expression analyses indicated significantly higher expression of HAS and HGF in FGF group. Conclusion: FGF was revealed to prevent vocal fold scarring through anti-fibrotic and possibly anti-oxidant effects. |
