The famous EPR argument [1] by A. Einstein, B. Podolsky and R. Rosen in the year 1935 expressed their historical view that Quantum mechanics could be completed into a form recovering classical ‘determinism’ at least under limit conditions. Santilli’s seminal contribution provided formulation of novel mathematical, physical and chemical methods to show that interior dynamical systems admit classical counterpart in full accordance with the EPR argument via representation by Isomathematics [ 2,4 ]. Moreover, Einstein’s determinism for strong interactions [3]  is progressively achieved in the interior of hadrons, nuclei  and stars and it is fully achieved in the interior of gravitational collapse known as isodeterminism  [ 6]. In this paper we investigate the metaphysical implications of the Hindu philosophical notion of ‘determinism’ in the light of Santilli’s  path breaking proposal as to ' ‘determinism’ can be established in the limiting sense at the core of a black hole [5,6].’  ‘Determinism’ is a philosophical view where all the events are completely determined by previously existing cause [7,8].  “Everything that happens has been predestined to happen by an omnipotent, omniscient divinity. We show that Santilli’s determinism (isodeterminism) is in tune with the ‘determinism’ prescribed in the Hindu philosophy.