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POTENTIAL OF ANTIOXIDANT TREATMENT FOR GREY HAIR AND HAIR LOSS
Yoshiaki Harakawa1; Fuhua Yang1; Kentaro Omoya1; Haruhiko Inufusa1
1Gifu University, Gifu, Japan

PAPER: 130/Oxidative/Keynote (Oral) OS
SCHEDULED: 13:40/Thu. 20 Nov. 2025/Dusit 2

ABSTRACT:

Human hair has various functions, including physical protection, insulation, and waste disposal function for the head. It also plays a significant role in social and aesthetic aspects. In many cultures, hair loss and greying are seen as undesirable signs of aging because they contradict the desire to appear younger.
In healthy individuals, around 90 hairs are shed daily and replaced by new hair within 4–6 months; however, factors such as lifestyle habits, stress and hormonal changes can disrupt this cycle, resulting in increased hair loss or delayed growth. Grey hair, on the other hand, occurs when melanocytes — cells that produce melanin, the pigment that gives hair its color — are damaged and can no longer produce melanin. Both conditions are known to be significantly influenced by oxidative stress.
Twendee X and Twendee M are mixed antioxidant supplements composed of vitamins and amino acids, for which safety tests have been conducted. Previous studies have shown that these supplements reduce oxidative stress in the body through their mitochondrial protective effects. In this presentation, we will discuss the potential of antioxidant treatment for grey hair and hair loss based on antioxidant data from the Twendee series, as well as questionnaire results and case reports from human participants.

REFERENCES:
[1] Seiberg M. Age-induced hair greying - the multiple effects of oxidative stress. Int J Cosmet Sci. 2013 Dec;35(6):532-8.
[2] Trüeb RM. The impact of oxidative stress on hair. Int J Cosmet Sci. 2015 Dec;37 Suppl 2:25-30.
[3] You F, Harakawa Y, Yoshikawa T, Inufusa H. Why Does the Antioxidant Complex Twendee X® Prevent Dementia? Int J Mol Sci. 2023 Aug 21;24(16):13018.