The COVID-19 pandemic has led to an increase in the number of people suffering from various diseases, with patients becoming younger. In addition, rising medical costs and drug shortages are exacerbating the situation, such as becoming impossible to adequately treat diseases that should normally be treatable, raising concerns about future health risks. As the current state of medical care is likely to persist, disease prevention will become increasingly important in the future. Inflammation is at the root of all diseases, including aging, common lifestyle-related diseases, designated intractable diseases, and even unknown diseases. Oxidative stress is closely associated with inflammation. Prolonged exposure to inflammation and oxidative stress can accelerate the onset of diseases, making it crucial to suppress oxidative stress. We have been investigating the effects of Twendee X and Twendee Mtcontrol, antioxidant combinations, on various diseases. While it is well known that oxidative stress increases with age, lifestyle factors are also closely related. These factors can be broadly categorized into preferences, diet, exercise, and sleep. We summarized the results of previous studies on how these factors increase oxidative stress and how they affect the body's homeostasis. Based on these findings, we discuss the importance of improving lifestyle through antioxidant supplements.