R.M. Santilli’s seminal contribution provides formulation of novel mathematical, physical and chemical methods to show that interior dynamical systems admit classical counterpart in full accordance with the EPR argument via representation by Isomathematics. The Lie-isotopic branch of hadronic mechanics, wherein a system of extended protons and neutrons in conditions of partial mutual penetration in a nuclear structure verifies the following properties: 1) Admits, for the first time, explicit and concrete realizations of Bohm’s hidden variables. 2) Violates Bell’s inequalities 3) Verifies the broadening of Heisenberg’s indeterminacy principle for electromagnetic interactions of point-like particles in vacuum into the isouncertainty principle of hadronic mechanics, also called Einstein’s isodeterminism for extended hadrons in conditions of partial mutual penetration. Moreover, Einstein’s ‘Determinism’ for strong interactions is progressively achieved in the interior of hadrons, nuclei and stars, and is fully achieved in the interior of gravitational collapse known as ‘Isodeterminism’. In this paper we study Santilli’s seminal work in verifying Einstein’s Determinism.