In Honor of Nobel Laureate Dr. Aaron Ciechanover
We review recent advances on isomathematics, genomathematics and hypermathematics for the invariant representation of reversible, irreversible and multi-valued systems of extended constituents in conditions of deep mutual entanglement, with conventional linear, local and potential interactions represented by the conventional Hamiltonian H plus non-linear, non-local and non-potential interactions represented by the operator S in the associativity-preserving iso-, geno- and hyper-completions 
, 
, of the millenary old associative product of operators 
, 
. We then review advances in physics, chemistry and biology which are permitted by iso-, geno- and hyper- mathematics, but impossible for 20th century applied mathematics [1] [2].
