Nanopatterned interfaces enable precise control over surface morphology and chemistry at the nanoscale, offering advanced capabilities in biosensing, molecular capture, and adaptive surface engineering. Their high-aspect-ratio structures enhance film integrity and allow spatially discrete functional domains. When combined with stimuli-responsive polymers, these surfaces can respond dynamically to environmental cues[1]. However, most existing systems incorporate only one type of responsive polymer, limiting their functionality and versatility[2]. Challenges in fabrication and chemical compatibility have hindered the integration of multiple responsive components into a single nanoscale interface. Recent advances in nanolithographic templating and surface-initiated photoinduced electron transfer-reversible addition–fragmentation chain transfer (SI-PET-RAFT) polymerization have enabled the creation of binary-patterned surfaces with independent spatial and chemical control[3]. We constructed a dual-responsive nanopatterned interface by integrating photothermal polypyrrole (PPy) with thermoresponsive poly(EGMEA-co-PEGMEA) brushes[4]. Nanoporous PPy films were prepared via colloidal templating and electrochemical deposition, followed by selective brush growth through SI-PET-RAFT polymerization. This binary system demonstrates the synergistic potential of combining multiple responsive elements within confined nanostructures. It offers a modular platform for multifunctional surfaces with applications in biosensing, targeted capture, and smart biointerfaces.