Dr. Go Kimura

Abstract:

The spray freeze-drying system is a type of freeze-drying method. This technology is a hybrid pharmaceutical manufacturing technology that combines the spray drying and freeze-drying which are existing manufacturing technologies [1].

Its introduction into the pharmaceutical industry has begun to be considered as an alternative manufacturing method to conventional freeze-drying technology [2].

Spray freeze-drying system can be applied to various pharmaceuticals regardless of modality. This technology has the potential to be a useful solution to formulation issues that were difficult to solve with conventional freeze-drying technology. Thus, it is expected that this technology, which can be used from the perspective of both formulation design and commercial manufacturing, will become more widespread in the future.

In this presentation, the case studies in Shionogi using sucrose and model liposomes with a view to applying spray freeze-drying to pharmaceutical development will be addressed [3]. The former case is a study aimed at applying spray freeze-drying to low molecular weight compounds, and the latter case is a study aimed at applying spray freeze-drying to soft materials.