Prof. Haruhiko Inufusa

Abstract:

In human brain tissue, oxidative stress (OS) induces various inflammatory cytokines, leading to inflammation. This inflammation causes diverse damage not only in the affected brain area but also in surrounding brain tissue.Long-term damage to brain tissue can impair the brain's autophagy function, reducing its ability to clear waste, leading to the accumulation of waste products such as amyloid beta and tau proteins, and creating a vicious cycle of further oxidative stress. Dementia is a representative disease of this process, and the development of pharmaceuticals has been challenging due to the diverse nature of the target waste products.Twendee X (TwX) is a supplement composed of eight vitamins, amino acids, CoQ10, and other ingredients, with clinical trial-confirmed preventive effects against dementia in humans. Other diseases closely associated with OS in brain neurons include hypertension, atherosclerosis, hearing loss/tinnitus, ALS, Parkinson's disease, post-stroke sequelae, chronic fatigue syndrome, depression, and sleep apnea syndrome.TwX is an antioxidant formulation that has been shown to be safe for use in both clinical and basic research, and it is expanding the field of antioxidant therapy, which has previously been challenging. The importance of antioxidant therapy is beginning to be recognized in the expansion of treatment targets for inflammatory diseases caused by oxidative stress in the brain and in basic research fields.