2018 - Sustainable Industrial Processing Summit & Exhibition
4-7 November 2018, Rio Othon Palace, Rio De Janeiro, Brazil
Seven Nobel Laureates have already confirmed their attendance: Prof. Dan Shechtman, Prof. Sir Fraser Stoddart, Prof. Andre Geim, Prof. Thomas Steitz, Prof. Ada Yonath, Prof. Kurt Wüthrich and Prof. Ferid Murad. More than 400 Abstracts Submitted from about 60 Countries.
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    Ultrasensitive Cell Recognition Based on Multifunctional Nanointerface
    Xuemei Wang1;
    1SOUTHEAST UNIVERSITY, Nanjing, China;
    PAPER: 207/Electrochemistry/Regular (Oral)
    SCHEDULED: 16:45/Mon./Copacabana B (150/1st)



    ABSTRACT:
    The early diagnosis of important diseases, like cancer, is still a hot topic in the relative areas involved in patient care and treatments. In this study, we explored the possibility of applying a combination of molecular probes and nano-scaled materials in biomolecular recognition and high-sensitive detection of diseases like cancers. In particular, we have developed a new strategy for the fast and high sensitive recognition of target biomolecules and cancer cells, by combining some new ferrocene-substituted carborane derivatives and functionalized nano-interfaces with the spectro-electrochemical study. Our observations demonstrate that the self-assembly of the specific nanocomposites with the new molecular probes could provide a multifunctional interface for the rapid identification of cancer cells, with a broad detection range and low detection limit. It is evident that different types of cancer cells or bacteria could be readily distinguished on the relevant nanocomposites' modified nano-interface, which have the promising application to be adopted as a significant way to detect various kinds of mutant cells and advance the clinic diagnosis and treatment of target diseases. Moreover, some ultrasensitive and intelligently multi-functional nanoscale biomarkers, based on the <i>in vivo</i> bio-synthesized nanoclusters through utilizing the peculiarities of the redox homeostasis from cancer cells, have been also explored for the real-time monitoring and multimodality imaging of cancer cells / exosomes or target tissues.

    References:
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    [2] C. S. Wang, J. Y. Li, C. Amatore, Y. Chen, H. Jiang, X. M. Wang, Gold Nanoclusters and Graphene Nanocomposites for Drug Delivery and Imaging of Cancer Cells, Angew. Chem. Int. Edit., 2011, 50 (49), 11644-11648.
    [3] D. H. Chen; C. Q. Zhao; J. Ye; Q. W. Li; X. L. Liu; M. N. Su; H. Jiang; C. Amatore; M. Selke; X. M. Wang, In Situ Biosynthesis of Fluorescent Platinum Nanoclusters: Toward Self-Bioimaging-Guided Cancer Theranostics. Acs Applied Materials & Interfaces 2015, 7 (32), 18163-18169.
    [4] X. L. Liu; H. Jiang; J. Ye; C. Q. Zhao; S. P. Gao; C. Y. Wu; C. H. Li; J. C. Li; X. M. Wang, Nitrogen-Doped Carbon Quantum Dot Stabilized Magnetic Iron Oxide Nanoprobe for Fluorescence, Magnetic Resonance, and Computed Tomography Triple-Modal In Vivo Bioimaging. Advanced Functional Materials 2016, 26 (47), 8694-8706.
    [5] L. M. Lai; C. Q. Zhao; M. N. Su; X. Q. Li; X. L. Liu; H. Jiang; C. Amatore; X. M. Wang, In vivo target bio-imaging of Alzheimer's disease by fluorescent zinc oxide nanoclusters. Biomaterials Science 2016, 4 (7), 1085-1091.
    [6] T. Y. Du; C. Q. Zhao; F. U. Rehman; L. M. Lai; X. Q. Li; Y. Sun; S. H. Luo; H. Jiang; N. Gu; M. Selke; X. M. Wang, In Situ Multimodality Imaging of Cancerous Cells Based on a Selective Performance of Fe2+-Adsorbed Zeolitic Imidazolate Framework-8. Advanced Functional Materials 2017, 27 (5), 1603926.