Among the modalities in the treatment of malignant tumor, chemotherapy is the 1st line of the tumor therapy due to its efficient and effective way, but a lack of specificity often causes an indiscriminate toxicity to normal cells. There have been many attempts to reduce its unwanted toxicities. Small molecules like monoclonal antibodies and receptor targeting agents get the attention for the new modalities. Recently radiopeptide therapies have got the world attraction for the tumor targeting modalities due to its beneficial effect on less side effect compared to cytotoxic chemotherapies including pain palliation. In nuclear medicine, 177Lu-DOTATATE is known to be a new modality as an effective one invented so far in treating neuroendocrine tumor (NET) and it has been in clinical trials in globally due to many beneficial effects. The study still should have been extended to overcome its less effective in the large solid tumor. To improve the effectiveness of radiopeptide therapy, potent small molecules were selected to target the tumor site selectively and its labeling with a radioisotope of emitting high-energy was confirmed through present study. Also, the present study was a focus to increase a biological half-life of radio somatostatin peptide which targets the somatostatin receptor by altering the bifunctional chelator (BFCA) and at the same time introducing moiety to increase its lipophilicity. The present study will introduce a new concept of a radio-peptide therapy in the neuro-endocrine tumor.

Arsenic bearing gypsum sludge derived from lime/ferrous sulfate precipitation process is one of the biggest hazardous wastes in nonferrous metallurgy (Cu, Ni, Pb, Zn, Sn, et al.) industry in China. Nearly one million tons of arsenic bearing gypsum (ABG) sludge with different heavy metals content and leaching toxicity should have been well disposed, but it is simply preserved in a reservoir. Precalcination is proposed to improve solidification/stabilization (S/S) of ABG sludge using Portland cement. The S/S performances of ABG sludge precalcinated at the temperatures range from (200-700 ¡aC) and untreated ABG sludge is investigated by means of compressive strength, leaching characteristics, microstructure, qualitative and Acid Neutralization Capacity tests. The arsenic leaching toxicity of precalcinated ABG sludge obviously decreases when the precalcinated temperature increases to 600 ¡aC and higher. More than 40% of cement is demanded to meet the requirement for safe disposal of fresh sludge using S/S process (compressive strength >10 MPa, toxicity <5mg/L) for the uncalcinated sludge while using only 10% of cement in S/S process reaches that requirement. The stability of solidified matrix from precalcinated ABG sludge is greatly enhanced. Precalcination results in high efficiency and dependability of S/S process of ABG sludge using cement.

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